Нужно создать статические записи в днс.
/ip dns static add name=apps.skype.com address=127.0.0.1
/ip dns static add name=api.skype.com address=127.0.0.1
/ip dns static add name=static.skypeassets.com address=127.0.0.1
/ip dns static add name=rad.msn.com address=127.0.0.1
/ip dns static add name=adriver.ru address=127.0.0.1
/ip dns static add name=devads.skypeassets.net address=127.0.0.1
/ip dns static add name=devapps.skype.net address=127.0.0.1
/ip dns static add name=qawww.skypeassets.net address=127.0.0.1
/ip dns static add name=qaapi.skype.net address=127.0.0.1
/ip dns static add name=preads.skypeassets.net address=127.0.0.1
/ip dns static add name=preapps.skype.net address=127.0.0.1
/ip dns static add name=serving.plexop.net address=127.0.0.1
/ip dns static add name=preg.bforex.com address=127.0.0.1
/ip dns static add name=ads1.msads.net address=127.0.0.1
/ip dns static add name=flex.msn.com address=127.0.0.1